Are you activating the trainer at the menu or in game? Running As Admin? Any older versions still on your PC?
[Edited by Jaks, 1/1/2021 9:44:02 PM]
I've done both. If I try to in game, I get pretty bad input delay until it attaches, so I prefer to do it at the menu.
I am running it elevated. I don't have any older versions anywhere.
Delete trainer and all files in
Learn how to make your own Trainer Cleaner for the above paths Here. Link
Reboot PC to clear excess memory, get a fresh copy of latest trainer and extract it. Run trainer as admin, read the instructions and try again. At times, a new game may be needed to resolve failed options if the data in your save file was altered. Use on a new game and test the option. If it now works, quit to main menu and load your save and try it again. May also need to run the game without the trainer first and play a bit so the save file gets updated to use possible new values.