Well honestly I am still not playing it has CD-projekt has not fixed such major bug not allowing players to play in full screen mode...
Do you have Crossfire (2x ATI cards)? If so, disable it and just use one. Also try lowering your screen resolution through Windows.
@Vannhelsing: What kind of crash do you have? Any specific error messages, or just the usual stopped responding/CTD?
Try to close as many programs as you can in the background, and try playing it after a fresh restart.
[Edited by Skyheart, 5/18/2011 6:54:22 AM]
I did try playing a fresh.
No errors...nada...just straight to the launcher.