Several times I have the problem with Dead NPC's that stop the progress of the game. In other trainers -- or sometimes with games that allow console commands --- it is possible to resurrect a NPC. Is this something to consider in this trainer ?
I am sure that Super Damage plays a role in this problem ---- and that NPCs far removed from where the Super Damage was used --- are affected by this.
I've seen the similar issue with super-damage. I do not use it for this reason. The first and last time I tried it was when approaching the London gate for the first time and all the people by the gate were dead 😄. I couldn't go through the scripted sequence where you have to fight the buttheads who are trying to bully people at the gate and take their food and stuff. It was early in the game for me so I simply restarted.