You are aware of constant signature updates for Defender and that they might change the way Defender performs its duty?
Delete everything you find in Defender's quarantine and clear the scan history completely. Also, wipe the Windows Temp folder and browser cache + cookies (all browsers!).
Create just 1 folder and exclude this folder in Defender. Move all your CH trainers in this folder. Move all downloaded zip files into this folder and extract them in there.
For our most current trainers (black/white user interface), you also need a folder exclusion for the Work folder located here -> C:\Users\YourWindowsUserName\Cheathappens\ - older trainers may create their tmp files in the Windows Temp folder and need special treatment.