No Reload seems to cause a CTD when you loot a melee weapon. A few people have mentioned it but I don't think Cal's commented on fixing it yet, or at least I've missed it in this 80-page thread.
i'll check it but telling me that the game crashes after a few minutes is useless information. we need something specific that occurs repeatably and is easy to reproduce. also, it's really helpful if people have savegames to use for this reason, since there is 1000 weapons, 1000 attachments mods, and 1000 locations in the game.