Thanks for your replay.
I'm using McAfee, and unfortunately it seems to me that it can allow to exclude files only, not directories. I got the Mc's latest version installed.
I could exclude the temp file each time that the trainer create it, but life should be easier I think.
Have you tried disabling McAfee's Realtime Scan to see if that helps?
After some testing, The only thing that works right is unlimited ammo. My character still took damage from creatures and radiation poisoning. Come to think of it perk points also didn't seem to click nor did xp.
I'll put this game to the side for now, can't get to Concord heck just getting out of Sanctuary was tough enough, (I selected Very Hard difficulty)
All options say activated but like I said before only one option sticks.
Which platform, Steam or Windows?