I had the same problem when I upgraded, but its very simple to solve.
When launching the trainer, win 10 will tell you that its unsafe software.
In the "Unsafe" software window, click on the "more information" link, and it will then let you run the trainer.
(The text is slightly different than what I'm writing, but once you click on the more info text it will become self explainatory)
Here's how to turn it off completely.
* Updated game trainers and cheats daily
* Get notified when new cheats are added
* Request which games get new trainers
* Priority support with any problem