Personally, I squeeze from the middle, but then I put the cap back on, and squeeze from the end so all the pasty goodness will be in the front.
Generally the middle, although when the tubes getting a little empty I press from the top but squeeze up the scraps from the bottom.
I don't squeeze my toothpaste. There is a can version (like a deodorant can) for lazy people like me where you just push down and toothpaste comes out.
If it's full I squeeze it from the middle. If not, I start from the bottom and end up at front.
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