as i already stated, you need to turn the options off at the end of the level, otherwise you will load up the next level with no left hand. Im not sure which option is causing the problem, but its easy enough to just turn everything off right before you finish a level.
I did disable before i move to the next level (going in Dinoyus Park level) after that level load, i alt tab and bring the trainer on then went back to the game and activite the trainer. I was going through fine and finally see a Houndini Splicer, there a sercet area that you need a keycode for. So after killing that splicer, i went up to the stair and got a audio dairy of a young boy who like a blond girl and told the keycode, so i went down to get in that area (it have Power to the People) then my left hand disappeared.
As i said, it happens even you not going on to the next level. Same thing happen to me in Siren Alley, There was a tonic in one bar but I can't access it, so only way is to go up on the second floor then get in one room that have a hole on the floor, so i jump in that hole and then my left hand disappeared, i got the hand back after i pick up the daughter or let the daughter harvest the corpse. It seem it happened random.
Im not sure if it was the trainer that affecting it. I dont have any plasmid cheat on. Only i have on is Heath, EVE, Money, Adam, Item/Fuel and no Reload.
After googling the problem, I found out the plasmid hand glitch is not the trainer problem, it was the design flaws. Many player from PC, PS3 and Xbox 360 reported the same problem with Plasmid Hand glitch. here the thread in 2K, forums.2kgames.com/forums/showthread.php?p=649449 and one person said there a way to fix it. I came across this as well, to remedy what i've done is try zooming in with a weapon and at the same time hit the respective button to cycle plasmids (LB for 360). Repeat this process until your plasmid hand reappears. Sometimes i'll have to go through all my plasmids, but usually when I reach incinerate or cyclone trap my hand reappears.
[Edited by aquafusiondane, 2/14/2010 5:27:14 PM]
[Edited by aquafusiondane, 2/14/2010 5:28:47 PM]