Ok here's what I've tried...
Running the game, loading from the Proving Grounds auto-save, escorting the Little Sister to Test Subject #1, with F12=god bound and active, she actually takes a slight bit of "damage" to her yellow bar now, and after the wave of attacks, she *does* finish up and begin moving toward Test Subject #2. This is progress.
Attempting to tab out and run the trainer at this point crashes the game. I'm not sure when, if ever, the trainer can be re-activated safely after this point, but I suspect this is the end-game anyway. I'll let you know what I find, if anything useful.
* Updated game trainers and cheats daily
* Get notified when new cheats are added
* Request which games get new trainers
* Priority support with any problem