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Started the game about half an hour ago, what's with the tumble weed? Is there anything else I need to know to start off the game well??

Congrats!
The tumbleweeds are nothing, they just roll around.
Ok, most of Frankie Fusillis missions are revolved around cash, like give him 1000 simoleons for Jimmy The Neck, etc. After you complete Frankie Fusilli, you move on to Ava Cadavra,her missions are easy. But at some point you need to find a sarcophogus. It is near the blue pond with palm trees, use the medal detector, its at the back. After you complete Ava Cadavras, you move on to Optimum ALFRED, which is HARD.
When he runs the first time, you have to defeat his minions, and he will come back, go, and they will come back. Do this untill the screen goes black, and the credits roll.
Well, that is all, lol.
Have fun!