So I know from seeing the teaser for the next Mass Effect game that it most likely has something to do with Shepard. I would like it if they would bring back Shepard, I just wonder how. If Shepard is somehow alive then the ending from Mass Effect 3 that has to be canon would be the destroy ending.
I sure hope they bring back Shepard in some way, as well as my favorites from the old crew. (Garrus, Tali, Mordin, Lara, Grunt, Anderson, Joker, Miranda) The only way I can think how they might do that would be to resurrect the main players from advanced DNA samples or something science fiction-y like that. I'd love to see another grand campaign of recruiting all the rogue clans like the Vorcha and Blue Suns, with everyone banding together to defeat the Reapers. That would even leave things open for another sequel where all the alliances fall apart and betray each other leading to . . . well, if I had my way they'd just keep making ME games with that cast until I'm too old to play video games anymore!!
I was deeply disappointed with the ME3 ending, what a dumb move. They had a killer franchise going there with an intensely loyal fan base and blew it! MEA was a very pretty game, but ultimately had little of the original's fantastic plotlines, characters and wit. (I love a game with a little wit) Here's hoping they don't screw this one up.