Please delete the trainer, custom keys, debug folder where the trainer resides and all files in
Learn how to make your own Trainer Cleaner for the above paths here
Reboot PC to clear excess memory, get a fresh copy of latest trainer and extract it. Run trainer as admin, read the instructions and try again. At times, a new game may be needed to resolve failed options if the data in your save file was altered. Use on a new game and test the option. If it now works, quit to main menu and load your save and try it again. May also need to run the game without the trainer first and play a bit so the save file gets updated to use possible new values. This typically will resolve the issue.
Please disable/uninstall all antivirus, firewall and other security software including browser addons and extensions. Right click "Run as Administrator" on trainer and game. Please note that some security products may still block access to trainer injection even when disabled and must be completely uninstalled. If this is the case, please contact the product vendor for instruction on the proper way to prevent the trainers from being blocked by their software or find a better alternative.
Extract trainer and make sure trainer/launcher/editor is in a folder excluded from virus scans. Empty quarantine folder if needed or set anything trainer related (paths and EXE's) to ALLOW. Disable any Live/Active/Real-Time tools which may trigger false positives in security software that may terminate the game/trainer when it's activated or options used.
may need to be added to exclusions as well. Click and select "Run as Administrator", read the instructions and try again.