You could try clearing stuff in:
%appdata%\Cheat Happens
and start the trainer and see if it helps. Otherwise it's likely an external issue. Please note that customized trainers have additional protection which might trigger additional security tools to interfere.
I know its been years since your post, but you just helped me fix my trainers. 😁 They all stopped working. After 2 hours on the net trying everything, thank god i found your post. %appdata%\Cheat Happens was the fix. Thank you very much 0x90: All hail
😁