Can't speak on those as I only have the samurai edge and the le5 didn't know there was a s+ 3 saves or less yikes
Same issue here. Had to restart the game without the trainer in order for the enemy script to start running, and even then there's something gimmicky - Claire doesn't take damage from the boss (or rather, the bosses attacks don't seem to land, and this is not with trainer deactivated, this is when the trainer program isn't even started). Also, if you do too much damage to the boss while on the container platform, it will eventually stop moving, at which point if it is not positioned in the right area, the container won't hit it, and you will be stuck on the container platform.
Be warned if you're going to use the Tyrant cheat, because you could run into some hassles late game.
I'm stuck as well! I have even reloaded and restarted the game without the trainer with Leon and I'm still stuck and Birkins doesn't seem to land any of his attacks on me. Before this all the zombies also don't land any hits on me. I don't know what the trainer did but it broke my game and I don't know how to fix it. Any ideas, guys?