Delete trainer and all files in
Reboot PC to clear excess memory, get a fresh copy of latest trainer and
make sure trainer in is folder excluded from virus scans. Empty quarantine folder if needed.
may need to be added to exclusions as well. Run trainer as admin and try again.
Anti-virus help page. Link
Mods and trainers do not get along, use one or the other. Very few times will a trainer work with a Mod installed. Un-install Mods then verify files via Steam. Link