Any chance you could provide some info on your specs, running OS and if the game's version matches the trainer's version?
Do you run the trainer with admin rights?
Tried compatibility mode?
Is any AV or other security software blocking the trainer? Tried to switch it off or white-list the trainer?
Are you using the Retail, Steam or GOG version?
Get rid of Windows Defender, worst A/V software out there, you might as well not have anything on your pc to protect it..
I won't make any recommendations on here, don't want to "Sell" anything but I will suggest that you Do Not go with Avast... I had it for a Very short while. It seems to really dislike Cheat happens files..