Delete trainer and all files in
Learn how to make your own Trainer Cleaner for the above paths Here. Link
Reboot PC to clear excess memory, get a fresh copy of latest trainer and extract it. Run trainer as admin, read the instructions and try again. At times, a new game may be needed to resolve failed options if the data in your save file was altered. Use on a new game and test the option. If it now works, quit to main menu and load your save and try it again. May also need to run the game without the trainer first and play a bit so the save file gets updated to use possible new values.
We know, I have posted that about a thousand times by now.
Extract trainer and make sure trainer/launcher/editor is in a folder excluded from virus scans. Empty quarantine folder if needed or set anything trainer related (paths and EXE's) to ALLOW. Disable any Live/Active/Real-Time tools which may trigger false positives in security software which may terminate the game/trainer when it's activated or options used.
may need to be added to exclusions as well. Run trainer as admin, read the instructions and try again.
Anti-virus help page. Link
You need to extract all the files from the .ZIP before you use the trainer. Be sure to extract them to a folder excluded from security software scans.
Disable any AV you might have active, and run the trainer as Admin.