Where do you own the game on?
Extract trainer and make sure trainer/launcher/editor is in a folder excluded from virus scans. Empty quarantine folder if needed or set anything trainer related (paths and EXE's) to ALLOW. Disable any Live/Active/Real-Time tools which may trigger false positives in security software which may terminate the game/trainer when it's activated or options used.
may need to be added to exclusions as well. Run trainer as admin, read the instructions and try again.
Anti-virus help page. Link
Will also not work on Linux or MacOS or if the game was modded to the point where the .exe was changed too much.
[Edited by CyPHeR369, 2/9/2021 5:12:00 PM]