The loading screen crashing is a known issue, unrelated to the trainer. The worst occurrance is during Mutant Bash TV, but it can occur anytime. I suggest using Quick Save (F5) at the door to any zoning in or out. It may be purely coicidence, but it seems for me and others on the Bethesda forums to reduce the occurance of crashes.
Also, research the Cache file 'fix', its OS dependent so may not be applicable to your system.
[Edited by OmniTree, 10/7/2011 4:40:45 AM]