Introduction
 Basics
 Walkthrough
 - Chapter 01
 - Chapter 02
 - Chapter 03
 - Chapter 04
 - Chapter 05
 - Chapter 06
 - Chapter 07
 - Chapter 08
 - Chapter 09
 - Chapter 10
 - Chapter 11
 - Chapter 12
 Database Files
 Locations
 Extras
 Downloads
 Credits
WALKTHROUGH - CHAPTER 05, LETHAL DEVOTION

== Tram Station ==

The --GO TO CHEMISTRY-- database file will play shortly after Isaac steps out of the tram.

ITEM LIST
[ ] --"Go to Chemistry" database file--

Objective Added:
[ ] Find the Chemicals

Kendra thinks she can create an agent that will poison and kill the creature on Hydroponics that contaminating the life support system. Bio chemistry is a little out of my field. I'll have to trust her.

 
   

There is a !!STORE!! on the wall to the left if you need to purchase any items or place anything in the safe. Walk down the hall ahead and enter the Security Station. View Screenshot

== Security Station ==

This room is now full of lanterns placed on the floor. The --SOMEONE ELSE-- database file will be received shortly after the intercom speech in this room and the door on the right will be unlocked shortly afterwards. There is a !!SAVE STATION!! next to the small room up ahead and a !!STORE!! on the right wall. Step behind the glass and open the --ITEM LOCKER--. Open the unlocked door on the right side of the room then continue into the next area.

ITEM LIST
[ ] --"Someone Else" database file--
[ ] Item Locker

== Imaging Diagnostics Hallway ==

 

Two Lurkers will appear as Isaac steps around the corner, View Screenshot so arm the Flamethrower and roast them with secondary fire flame bursts. Continue around the corner then open the next door. There is a stasis recharger to the right after moving under the doorway in the hall - be sure to recharge if needed before entering the next room.

== Imaging Diagnostics Room ==

There is an --ITEM LOCKER-- inside the room to the left and an !!UPGRADE BENCH!! off to the right. Move up the ramp on the right side of the room.

ITEM LIST
[ ] Item Locker

Before moving all the way across, look on the left wall up ahead and find the fleshy organic sac on the wall that looks much like a baby. Besides one other enemy, that is the most annoying enemy in the game right there my friend, but it has one weakness that will do it in with one hit. Walk back and kinesis grapple the red explosive canister near the ramp and bring it across the ramp with you. When you get to the other side, the Spawner (the wall creature) will begin to send out its appendages along the wall around it.

These annoying things shoot out pods that will stick to the ground and tentacle will surface from the pods and try to hit Isaac with projectiles. The pods can be destroyed, but the Spawner will continue to shoot out more. The pods are the most annoying factor in the battle with a Spawner since the pods will explode if Isaac is next to one and the tentacle will shoot acid balls at him. Don't ever get in close range to a Spawner or it will perform its instant kill attack on Isaac - a sharp appendage quickly cuts off hit head. In order to defeat one of these, all the appendages that it spreads along the wall around it must be destroyed, so any type of weapon that covers a wide area will work really well for these.

If you brought the red explosive canister with Isaac then simply wait for its appendages to attach to the wall around it then launch the explosive canister at it to kill it instantly! Always look for an explosive canister in the immediate area when facing one of these, otherwise, the Force Gun's secondary grenade fire sometimes works wonders for these enemies thanks to the wide area that it covers. This doesn't always work supremely well though. If you use a gun, then shoot it with stasis right off the bat to limit its pod shooting. Keep in mind that it will still perform its instant kill move just as quickly from short range even when under the influence of stasis!

 
   

Take the lift up to the top walkway in this room. Approach the moving platform up ahead and shoot the Lurker on the other side with flame bursts. View Screenshot Wait for the platform to move by then shoot it with stasis to slow it down so Isaac can run across it. View Screenshot It is very possible to make it across without using stasis for those risk takers out there!

Move to the other side and use the stasis recharger. Slow the platform with stasis once again then run across it. You could actually slow it with stasis then run back to the recharger and recharge then quickly run across the platform if want to. As Isaac moves toward the next door the --DNA NEEDED-- database file will play and a new objective will be initiated.



ITEM LIST

[ ] --"DNA Needed" database file--

Objective Added:
[ ] Find the DNA Sample

There is a sample of the necromorph DNA somewhere on this deck. Kendra needs me to find it to mix with the Chemical Capsule. In order to target the creature's pathology.

Save your game at the !!SAVE STATION!! on the left wall then open the door ahead.

== Zero G Therapy Area ==

Enter the Chemical Research Hallway through the unlocked door.

== Chemical Research Lab Hallway ==

Get on the lift off to the left then take it down. Pick up the --MERCER'S EXPERIMENT 1-- database file. Enter the room off to the left up ahead.

ITEM LIST
[ ] --"Mercer's Experiment 1" database file--

== Chemical Research Lab ==

Ah, in here we have test tubes full of creatures waiting to feel Isaac's wrath! Snatch the --FORCE ENERGY SHEMATIC--, the --1000 CREDITS-- and --POWER NODE-- in between the test tubes on the left side of the room. Open the --ITEM CHEST-- and smash the --ITEM BOXES--. Walk over to the desk up ahead then choose to load the chemical agents. Pick up the ++CHEMICAL CAPSULE++ when it appears.

ITEM LIST
[ ] Force Energy Schematic
[ ] 1000 Credits
[ ] Power Node
[ ] Item Chest,
[ ] Item Box
[ ] Item Box
[ ] ++CHEMICAL CAPSULE++

Objective Complete:
[X] Find the Chemicals

 

Dr. Mercer will make his introduction behind glass to the right. View Screenshot Listen to the good doctor then the maniac will let loose his experimental creature from the test tube across from him.

Let me introduce you to the Regenerator. View Screenshot Its head, both arms and both legs can all be shot off, but there is one problem - it cannot die through weapon blasts. Isaac can only slow it down by crippling it. Stasis is the best option to slow these enemies in order to get away from them. So what do you do now since the door is now locked and Isaac is trapped? You run. It's very easy to keep the Regenerator at a distance since it is so slow, just make sure to turn the camera to keep up with it when Isaac dashes away from it. Remember that you can still run while backing away. You don't have to use stasis or fire any bullets at it to get through this part.

Isaac must circle around the room until the --INDESTRUCTIBLE-- database file is received (Kendra will contact him). Kendra will unlock the nearby door. When the door is unlocked, shoot the Regenerator with stasis to halt him then unlock the door - remember that these doors don't open instantly. Haul ass through the door and reenter the hallway.

ITEM LIST
[ ] --"Indestructible" database file--

 
   

Note: The Regenerator will not pass through the doorway into the outside hall. View Screenshot You can stand at a distance away from the door and watch him pace back and forth. I am sitting here typing this while waiting on him and he hasn't move through it yet! And he won't.

== Chemical Research Lab Hallway ==

Open the newly unlocked door leading to the Imaging Diagnostics Room then step inside.



== Imaging Diagnostics Room ==

 

Spiders will crawl out from the hole in the wall View Screenshot above the middle ramp as the --HAMMOND ON HYDROPONICS-- database file plays. Take out the Force Gun and shoot the group with a pulse grenade (secondary fire) or use a Contact Beam's secondary fire and blast them while they are near Isaac. More Spiders will appear from the other side of the ramp once Isaac moves toward the middle of it, so be prepared to blast them as well.

Any shot from the Force Gun works incredibly well for these Spider enemies. The Regenerator can be heard as he prowls the surrounding rooms while you move through this one. Step through the door that leads to the hallway on the other side.

ITEM LIST
[ ] --"Hammond on Hydroponics" database file--

== Hallway to Imaging Diagnostics ==

The Regenerator will make a slight cameo appearance as he reaches through the left vent in this room but he'll quickly retreat because he sees you're using Berserker's walkthrough. View Screenshot Use the stasis recharge up ahead then circle around the corridor ahead and reenter the Security Station. The Regenerator will stomp along the next floor but he won't attack.

== Security Station ==

The --CREATING THE POISON-- database file will play upon reentering the Security Station. Be sure to save your game then enter the Clinic Hallway on the far side of the room.

ITEM LIST
[ ] --"Creating the Poison" database file--

== Clinic Hallway ==

Walk to the Clinic at the end of the hall.

== Clinic ==

Dr. Mercer will appear in the room up ahead and blabber a bit then leave. View Screenshot The door to the right will unlock when he leaves. Seems like a trap to me...

== Emergency Room ==

 
   

The room is silent as Isaac enters, and there are quite a few pickups in here that need to be horded. Sadly, Slashers and the Regenerator from before will appear in this room. Lurkers will show up once many of the Slashers have been defeated. Your main goal for this room is to defeat all other enemies besides the Regenerator - he can't be defeated in here! View Screenshot

Shoot one of the Regenerator's legs off to slow him down considerably then slow the Regenerator down even more with stasis and focus all of your firepower on the Slashers and Lurkers. This can be a very dangerous room if you allow the Regenerator to run freely. If you run from him while he has all appendages, he will jump into a vent on the ceiling then fall down near Isaac eventually. Be sure to stun him with stasis and keep him stunned most of the time. Use the Line Gun to chop through groups of enemies at once and switch to the Force Gun to simply get them off of Isaac if they start to pile up. Switch to either the Flamethrower or Plasma Cutter to deal with the Lurkers. View Screenshot

For locations of item pickups, --RANDOM AMMO-- is on the floor to Isaac's right when you first enter, --RANDOM AMMO-- is on the next bed to the right as you walk forward, --RANDOM AMMO-- is near the far right corner on the other side of the room, --1,000 CREDITS-- is on a bed on the other side of the room and there are two --ITEM LOCKERS-- in the small room across from the locked door on the other side. I wouldn't recommend going into the room with the Item Lockers - it's risky since Isaac can get trapped easily.

Once the other enemies besides the Regenerator have all been defeated, the --DOOR OPENED-- database file will be received. This is your cue to run toward the door that leads to the ER Hallway and open it then quickly step inside. The Regenerator will not follow.

ITEM LIST
[ ] Random Ammo
[ ] Random Ammo
[ ] 1000 Credits
[ ] Random Ammo
[ ] Item Locker
[ ] Item Locker
[ ] --"Door Opened" database file

== Emergency Room Hallway ==

There is some --RANDOM AMMO-- to the left as soon as you enter this room. Enter the room through the door on the right side and open the two --ITEM LOCKERS-- inside.

ITEM LIST
[ ] Random Ammo
[ ] Item Locker
[ ] Item Locker

 

You see that red canister right at the turn up ahead? View Screenshot Grab the canister with kinesis and carry it down to the other end of the hall. A Spawner is on the left wall, near the door at the end of the hall. Launch the canister at him when his tentacles move out of his chest to finish him for good. View Screenshot

Pick up the --GOLD SEMICONDUCTOR-- on the floor to the left of the Spawner. View Screenshot Move down the hall further ahead instead of entering the next room for now. A laughing woman stands near a bed at the end of the hall. View Screenshot You can't interact with her in any way. What's so funny!? View Screenshot Creepy. Pick up the --RANDOM AMMO-- and --2500 CREDITS-- near her. Notice the oxygen recharger on the far wall - keep it in mind for later. Journey back to the door at the end of the hall and open it.

ITEM LIST
[ ] Gold Semiconductor
[ ] 2500 Credits
[ ] Random Ammo

== Intensive Care Unit ==

There is a --RANDOM AMMO-- pickup on the other side of the second large test tube on the left wall. View Screenshot Be sure to save your game at the !!SAVE STATION!! across from the unlocked door. Step into Dr. Mercer's Office.

ITEM LIST
[ ] Random Ammo

 
   

== Dr. Mercer's Office ==

Maybe Dr. Mercer isn't all that bad. He left behind a --MEDIUM AIR CAN--, --1000 CREDITS--, --GOLD SEMICONDUCTOR--, and two --ITEM BOXES-- on the left side of the room along with the --MERCER EXPERIMENT 2-- database file on the right side of the room. If I were truly evil, I sure as hell wouldn't leave all of that for you. View Screenshot

Walk over to the controls in this room and load the chemical agent onto the table mixer. View Screenshot The mixer will take the chemical then provide Isaac with the ++CHEMICAL CAPSULE DNA++


ITEM LIST

[ ] Medium Air Can
[ ] 1000 Credits
[ ] Gold Semiconductor
[ ] Item Box,
[ ] Item Box
[ ] --"Mercer Experiment 2" database file--
[ ] ++CHEMICAL CAPSULE DNA++

Objective Complete:
[X] Find the DNA Sample

Once the capsule has been taken, the --INTERRUPTED-- database file will be received. Dr. Mercer will turn off the air for the surrounding portion of the Ishimura and the whole area will enter a vacuum. It seems I was being too gentle with Dr. Mercer. He really does need a leg appendage shoved up his ass.

SPECIAL NOTE: To get a head start on leaving, you can move out of this area while the "Interrupted" database file plays and this will help out greatly in getting to the Security Station without loosing much oxygen.

ITEM LIST
[ ] --"Interrupted" database file--

Objective Added:
[ ] Restore Life Support

Mercer just flushed all the air out of the Medical Deck! I've got to get back to the Security Station to seal the breach!

Isaac needs to get back to the Security Station to turn on the Life Support and restore air to this entire area. Quickly move back outside.

== Intensive Car Unit ==

Reenter the ER Hallway.

== ER Hallway ==

 

If you move all the way down the left side, there is an oxygen recharger at the far end of the hall. While moving down the corridor to the Emergency Room, a group of Spiders will attack, View Screenshot so take out your Force Gun and fire a force grenade at the group to get rid of the majority of them or use the Contact Beam's secondary fire on the group. Run to the Emergency Room.

== Emergency Room ==

Oh, good lord. Two Pregnants have now joined the Regenerator in this room. View Screenshot Run inside and shoot whatever gets in your way with stasis. There is an oxygen recharger on the right wall toward the middle portion of this room. Run to the door on the opposite side and reenter the Clinic.

== Clinic ==

Enter the Clinic Hallway.

== Clinic Hallway ==

Lurkers will move through the hole in the wall in here but just ignore them and open the door to the Security Station at the end of the hall. View Screenshot

== Security Station==

 
   

Run inside the room past the left wall and move over to the life support controls then activate the life support controls to restore air to the this portion of the ship. View Screenshot

Objective Complete:
[X] Restore Life Support

The --FINISH THE POISON-- database file will be received after air is restored and a new objective will be added.




ITEM LIST

[ ] --"Finish the Poison" database file--

Objective Added:
[ ] Create the Poison

With the DNA combined with Kendra's chemical mixture, I just need to run it through the chemical station again to create the poison.

After what all you just went through, I feel a visit to the nearest save station is in order. Enter the Imaging Diagnostics Hallway on the opposite side of the room.

== Imaging Diagnostics Hallway ==

Continue around the side of the hall then enter- oh, didn't see that coming! The door on the other side will slam shut then reopen as Isaac gets close to it. View Screenshot --THE LEVIATHAN-- database file will be received after the little startle at the end of the hall. Be sure to recharge your stasis at the nearby stasis recharger (you're going to need it before entering the next room).

ITEM LIST
[ ] --"The Leviathan" database file

== Imaging Diagnostics ==

Walk across the ramp to the right and reenter the Chemical Research Lab Hallway. View Screenshot

== Chemical Research Lab Hallway ==

Reenter the Chemical Research Lab where we first fought the Regenerator.

== Chemical Research Lab ==

Load the Chemical Capsule DNA onto the mixer and it will create the ++POISON CAPSULE++. The --POISON CAPSULE COMPLETE-- database file will be received after taking the capsule.

Objective Complete:
[X] Create the Poison

ITEM LIST
[ ] ++POISON CAPSULE++
[ ] --"Poison Complete" database file--

Objective Added:
[ ] Go to Hydroponics

Mercer got away. I can only hope one of his beloved necromorphs finds him before I do. Now that I've got the poison, it's time to go to the Hydroponics deck and kill that Leviathan creature before the air is totally contaminated.

The --SECRET LAB REVEALED-- database file will be received following the other file. The door to the side will now unlock, so enter the new side of the outside hallway.

ITEM LIST
[ ] --"Secret Lab Revealed" database file--

== Chemical Research Lab Hallway ==

 

Walk around the right side of this area and smash the --ITEM BOXES-- near the debris. View Screenshot Run back to the other side and keep moving down the corridor ahead. There are four --ITEM LOCKERS-- up ahead that can be opened and there is a !!SAVE STATION!! on the wall across from them. Enter the Cryogenics Lab up ahead.

ITEM LIST
[ ] Item Box
[ ] Item Box
[ ] Item Locker
[ ] Item Locker
[ ] Item Locker,
[ ] Item Locker

== Cryogenics Lab ==

Dr. Mercer will be behind the glass window to the left as Isaac enters this area. View Screenshot He must really fear becoming victim to a good 'ole shoulder button stomping.

You can collect the --RANDOM AMMO-- and smash the three --ITEM BOXES-- found around the room right now, but I would wait until you finish the main problem in this room first. You can also collect the goodies while Dr. Mercer talks if you wish.

ITEM LIST
[ ] Random Ammo
[ ] Item Box
[ ] Item Box
[ ] Item Box

 
   

The Regenerator and a few Lurkers will attack after Dr. Mercer finishes talking. View Screenshot Isaac must defeat the Regenerator to leave this room. What in the world can you do with something that will not die? You contain it! But how? View Screenshot

There is a cryogenic freezing chamber in the middle of this room. The controls for the cryo chamber are in the control room where Dr. Mercer appeared. Right when the Regenerator first appears, stand on the opposite side of the freezing chamber and allow him to walk into the middle of the chamber then stun him with stasis - it wouldn't hurt to shoot off his leg also. Quickly run up either ramp on the other side of the room that leads to the control room where Mercer was then open the door at the top and approach the controls in the center then activate the freezing process. If you are fast enough then the chamber will freeze the Regenerator and he will be contained and defeated. View Screenshot

If you need more stasis then there is a stasis recharger in the area with the cryo chamber. If the Regenerator moves too fast for you then blast off one of his legs while he is in the cryo chamber or you might want to cripple him completely by blasting off his appendages until he is forced to regenerate.

The --GOT THE POISON-- database file will play after the Regenerator has been frozen and the door in the control room will unlock. Be sure to collect the nearby --1000 CREDITS--, --RANDOM AMMO-- and -- POWER NODE-- before leaving the control room. View Screenshot

ITEM LIST
[ ] 1000 Credits
[ ] Random Ammo
[ ] Power Node
[ ] --"Got the Poison" database file--

== Tram Station ==

Run down the hallway ahead to get to the tram. Grab the --1800 CREDITS-- from the middle of the sitting area. View Screenshot Get on the tram and interact with the controls like usual to end this chapter.

ITEM LIST
[ ] 1800 Credits

 

[ back to walkthrough - chapter 04 ] [ continue to walkthrough - chapter 06 ]