Hello there,
Exactly the same problem. I was re-playing the game after some nostalgia for good old Shepard and I didn't want to go all through the hassle of gaining experience again to see the differences between backgrounds and stuff. That week I got the IE10 update and the trainer stopped working at startup.
Maybe someone can doublé check that? I really like that game and the trainer made it soooooo much easier to explore all character's possibilities.
If that is the case, a complete uninstall of IE10 may fix your problem. Some trainers will not function with IE10. This is a fairly common issue.