So GTA 4 causes the red ring of death now? Because that's now what I have.
No, GTA doesn't cause it per se. All games contribute to it because of the 360's poor design. The best thing you can do to prolong its life is only operate it in a room with a very low ambient air temp (i.e. air con cranked), make sure there is good air cirulation all around the 360 (i.e. don't shove it in an entertainment unit!), and never turn off the 360 while a game is running - always go back to the dash once you are finished playing and let it idle for 10-15 minutes so the exhaust fans can cool it down.