Have a small issue witrh the trainer - otherwise it works fine.
THe trainer doesn't "sense" when the game's exited and reset itself, so you can run the trainer, then the game, play for a bit, exit the game (which I have to do due to memory issues), then re-run the game and have the trainer not work until I re-run the trainer, which involved exiting the game, etc.
It's a minor annoyance, a annoyance nonethless though.
Most trainers have a checksum value when options are enabled. So when you quit the game and reload the memory where the trainer had changed is back to normal, and the trainer still thinks its enabled the function.
You could do the following, reset all options back to normal and then try each option. This seems to be the logical choice.
What all options do you have turned on? One hit kills? This might be a scripted sequence where that option shouldn't be used.
With a boss you can have this problem that it blacks the screen out (and if you use a spell that it gets stuck doing that spell).
If you used the spell there is no fix if the screen just blacks out you go to the menu -> quit -> NO (as in, don't quit) and the screen should be good again.
That's just for me though