Hopefully the hot fix patches don't happen too often to overwhelm Cal and the team. They only threw the one out yesterday because it looked very promising to help with performance, and the one the other day because they had a pretty horrible red sky bug with the first patch.
Once you confirm that the trainer is working on your machine, here's some solid advice: go offline. Steam is sneaky about the updates they push for the game. Even when they're not sneaky (ie, they said they'd be patching every Friday), our trainers take longer than a few minutes to make. So just use offline mode for Steam, or take your entire computer offline if you'd like. Whenever we have a trainer for the updated version, THEN you should go online, download the patch, rinse and repeat. It's a win for everyone. You enjoy your patch, we don't get 25 "trainer isn't working, when's the new one coming" posts.
I can't get any of the trainers to work for Rome 2 on my pc. My game is also up to date and using the latest trainer. Pressing f1 won't do anything and it kept saying numlock is turned off. If I can just hear the trainer activated message, I would pass out from over excitement. And thanks for creating all these wonderful trainers especially for Sins of the Solar empire: Rebellion. Wish there was a Star Wars mod for it.