I think I must be doing something wrong in the final mission. During the fight with the Invisible Beast I continually kick the heck out of him, but all he does is stop, howl, then regenerate and I have to beat him down all over again... which just goes on and on and on. What does it take to finally kill him. I have the magic glasses, the magic ax, and I press the action button to get Josie's blood... Just can't get the bastard to croak!
Once you have the blood of Josephine, you have to beat the beast to no health, and then he starts to look dizzy. Once he's like this, you have to shoot him with the blood bullet before he regens. Every time you take a shot, you lose the blood bullet, so make sure you don't shoot your gun until the right moment.