1.) If you haven't read all of the "Trainer Troubleshooting" page, check it out.

2.) Another thing to try would be using a "no-cd", "fixed", or "cracked" executable file.

Using those kinds of "no-cd" .exe files has fixed some of my issues.

...especially if the trainer is designated for "Retail Version" and I have a Direct2Drive, Steam, or similar version.

Be sure to post back if any of that helps, or you otherwise get it working.

-cheers