KoA should be played pretty much without the inventory extra cheat as there are just too many locations/quests which break once you have it started.
The Main questline before you head into the Tuatha stronghold, the quest with rescuing soldiers trapped and you have to enter a sewer pipe (you get poisoned and need a potion), as well as not being able to also enter the castle near that same location once you obtain the castle as its ruler in order to find the gardener.
I imagine there are a few more times this happens but as I did not get past this, I cant say what else is broken.
I do know you keep the curse of -50% Mana on you as you cannot complete that quest with drinking the potion (which I did after finding it) - it did not update the quest as completed. I then tried to return to a healer for curse removal, but its a "special" curse only obtained through the quest so you cannot remove it through another means.
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