Gratitious Space Battles (Or something like it): This has cartoon like 2D graphics but is really fun.
Star Trek DAC: Not sure, but this really is an old school game. Enjoyed it.
Sins of a Solar Empire: One of the best strategy games I have ever played. Not sure if this fits in the genre, but you control space ships.
Space Empires V: Average game, but you may like it.
[Edited by HonestGamer, 2/22/2011 9:23:39 AM]
Star Trek Bridge Commander Game..is old..but its a very good game. regarded as one of the best of its series.
Hope this helps.
If you own an ATI card, you might get graphics corruption in XWA even after upgrades. I still can't figure it out and have given up.