I did. I used the "no radiation damage" option of the trainer anyway. "SPOILER"---->You find many feral ghoul and the shining ones. However I didn't opened the level 100 safe, but the armory is full of weapon, there is also the All-American rifle that, if i'm not wrong, you can find only in this vault. If you question is only related to what is in the 100 safe, well, I'm sry >.< you should just check fallout new vegas wiki and find out.
Well there is a quest related to the NCR Sharecroppers Farm Spoiler:
You can deactivate the reactor to save the NCR sharecroppers farm or delicate control to vault dwellers trapped somewhere else while screwing over the sharecroppers farm. (I bet they're already dead anyways)
The pulse gun doesn't just do great damage to robots, it was designed before the war (a prototype) to be very powerful against power armor because America was worried the commie Chinese were going to develop the tech but the end of the world happened before the guns could be mass produced.
ALSO, in the armory is a detonator. What is the detonator for you might ask? Well, if you reverse pick-pocket some C-4 into a persons clothes, just dropping the C-4 into them..you can whip out the detonator and blow them up.