I agree it won't win lol but it's my number 1 because I am not a fan of Star Craft. We all the know the number one best selleing game on the market for 2010 will be Black Ops any ways.
I love ME2, started playing for the ummmm... 7th? no 8th time last night. So awesome.
well..on this poll ME2 is way ahead of the rest. i've played it with ME1 save game about 12 times i think so far but a few months down the line things could change with Force Unleashed 2/Lost Planet 2/MOH and Black Ops coming out.