"****" - Over 215 uses (dozens of which are in a sexual context)
"****" - Nearly 70 uses
In addition, there are dozens of uses of various different slang terms for male and female genitalia, including "C***". There are also a few racial slurs (said by the black character), including as the name of a production company ("Nigga Rich Productions").
One scene includes a very drunk male coming into the coffee shop to get coffee so he can drive.
The entire cast is seen drinking at Zack and Miri's house after the water and electricity were turned on.
Deacon is seen playing a drinking game (Quarters).